Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine p815 model
✍ Scribed by Yuzhang Wu; Ying Wan; Jiang Bian; Jianping Zhao; ZhengCai Jia; Liyun Zhou; Wei Zhou; Yang Tan
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- French
- Weight
- 162 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The efficacy of phage display particles expressing tumor antigen P1A35‐43 in inducing protective and therapeutic anti‐tumor immune responses were studied. A protective immune response against a lethal progressive P815 mastocytoma tumor cell challenge was established after subcutaneous injection of phage display particles. Furthermore, the vaccine suppressed growth of pre‐existing tumors. Immunization with the hybrid phage particles elicited P1A~35–43~ specific CTL responses and a Th1‐dominated immune response with phage particle‐specific secretion of IFN‐γ but not IL‐4. Our results indicate that phage display particles might be a useful vaccine form for tumor‐associated antigen epitopes in tumor immunotherapy. © 2002 Wiley‐Liss, Inc.