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pH-sensitive drug delivery systems by radical polymerization of gelatin derivatives

✍ Scribed by I. Altimari; U. G. Spizzirri; F. Iemma; M. Curcio; F. Puoci; N. Picci

Book ID
112001868
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
970 KB
Volume
125
Category
Article
ISSN
0021-8995

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## Abstract A novel pH‐sensitive nanoparticle drug delivery system for doxorubicin (DOX) is prepared. Pullulan, a natural biocompatible polysaccharide, was partly carboxymethylized; hydrazine hydrate was condensed with the carboxyl groups forming hydrazide. The hydrazide was coupled with DOX throug