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pH-dependent isomerism of (Iso)thioureidomethylenebisphosphonates

✍ Scribed by A. L. Chuiko; L. P. Filonenko; A. N. Borisevich; M. O. Lozinskii


Book ID
111459943
Publisher
Springer
Year
2009
Tongue
English
Weight
160 KB
Volume
79
Category
Article
ISSN
1070-3632

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The biotransformation of roxithromycin in simulated gastrointestinal fluids at 378C and in rats was investigated by using liquid chromatography-tandem mass spectrometry. Roxithromycin degraded to its Z-isomer and decladinose derivative in simulated gastrointestinal fluids in vitro at pH 3, and follo