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pH Dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI

✍ Scribed by Dale L. Boger; Christopher W. Boyce; Douglas S. Johnson

Book ID: 104364748
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 278 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00605-1

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✦ Synopsis

A study of the DNA alkylation rate pH dependence with the establishment of pseudo first-order rate constants for 1 and 3 at a single high affinity site in w794 DNA is detailed. This dependence proved to be remarkably small with the rates increasing only 1.89x and 2.5x, respectively, over 2 pH units (pH 6-8).

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