pH dependence of protamine action on apical membrane permeability in Necturus gallbladder epithelium

Dose dependency in the oral bioavailabil

Dose dependency in the oral bioavailability of an organic cation model, tributylmethyl ammonium (TBuMA), in rats: Association with the saturation of efflux by the P-gp system on the apical membrane of the intestinal epithelium

✍ Moon Kyoung Kim; Liwei Han; Min Koo Choi; Yong-Hae Han; Dae-Duk Kim; Suk-Jae Chu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 1 views

The oral bioavailability of tributylmethyl ammonium (TBuMA), an organic cation (OC), exhibited a dose-dependency (i.e., 17, 27, and 35% at doses of 0.4, 4, or 12 micromol/kg, respectively) in the rat. Relevant mechanisms were investigated in the present study by estimating the mucosal to serosal (m-