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pH dependence of penicillin amidase enantioselectivity for charged substrates

✍ Scribed by Karsten Lummer; André Rieks; Boris Galunsky; Volker Kasche


Book ID
114149993
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
261 KB
Volume
1433
Category
Article
ISSN
0167-4838

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## Abstract Cathepsin B is a cysteine protease that in tumor tissues is localized in both acidic lysosomes and extracellular spaces. It can catalyze the cleavage of peptide bonds by two mechanisms: endoproteolytic attack with a pH optimum around 7.4, and attack from the __C__‐terminus with a pH opt