pH Dependence of fluorescence and absorbance spectra of free sulphonated aluminium phthalocyanine and its conjugate with monoclonal antibodies

✍ Scribed by A.P. Savitsky; K.V. Lopatin; N.A. Golubeva; M.Yu. Poroshina; E.B. Chernyaeva; N.V. Stepanova; L.I. Solovieva; E.A. Lukyanets

• Book ID: 103994267
• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 387 KB
• Volume: 13
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/1011-1344(92)85073-4

✦ Synopsis

Water-soluble phthalocyanines and phthalocyanines linked to targeting monoclonal antibodies are considered to be one of the most promising photosensitizers in photodynamic therapy. Here the spectrum characteristics of sulphonated aluminium phthalocyanine and its protein conjugate in the pH range 1.8-12.0 in solution have been studied. The pK values are determined.