pH-Controlled drug release from mesoporous silica tablets coated with hydroxypropyl methylcellulose phthalate
β Scribed by Wujun Xu; Qiang Gao; Yao Xu; Dong Wu; Yuhan Sun
- Book ID
- 113786542
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 643 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0025-5408
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Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB