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pH- and Temperature-Sensitive Chitosan Hydrogels: Swelling and MRI Studies

✍ Scribed by Francisco M. Goycoolea; María E. Fernández-Valle; Inmaculada Aranaz; Ángeles Heras

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
413 KB
Volume
212
Category
Article
ISSN
1022-1352

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✦ Synopsis

Abstract

MRI and swelling experiments are used to probe the state of water and infer the microstructure of chitosan hydrogels. SEM reveals a porous open scaffold‐type structure for hydrogels that were equilibrated at 2 °C before freezing as compared to those equilibrated at 37 °C. ADC MRI measurements reveal an anisotropy in the microstructure of these gels. T~1~ relaxation MRI values were larger as the pH increased from 7.6 to 12.0, the result of a lower rate of exchange between protons of the hydration sphere of the polymer and bulk water. The thermosensitive and pH‐sensitive properties of these hydrogels can be utilized in the development of innovative materials for biotechnological and biomedical applications, including criobiocatalysis and bioremediation as well as in programmed drug delivery. magnified image

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