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PGE-1 in replantation and free tissue transfer: Early preliminary experience

✍ Scribed by José Manuel Rodríguez Vegas; María Elena Ruiz Alonso; Pedro Pablo Terán Saavedra

Book ID
102508828
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
125 KB
Volume
27
Category
Article
ISSN
0738-1085

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✦ Synopsis

Experimental and clinical trials demonstrate the vascular, anti-ischemic and tissue protective effects of PGE1, which has been used for many years in different macrovascular diseases. However, few reports have addressed its potential use in microvascular surgery. The authors share their early experience with PGE1 in replantations and free tissue transfers. Considering its established benefits and minimal adverse reactions, PGE1 might be included as a first-line medication in the antithrombotic pharmacologic treatment in replantation and free flap surgery. However, the overall clinical efficacy and safety of PGE1 in microvascular surgery remains to be determined in larger, prospective clinical trials.

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