PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2

Adenosine induces hemeoxygenase-1 expres

Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2

✍ Kyoung-Jin Min; Jong-Hyeon Kim; Ilo Jou; Eun-Hye Joe 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 920 KB

## Abstract Adenosine, a purine nucleoside, has been reported to suppress the inflammatory responses of microglia in the brain. However, the underlying mechanisms of its anti‐inflammatory action are unclear at present. Here we show that adenosine reduces the increase in intracellular reactive oxyge