PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells

Ras-induced colony formation and anchora

Ras-induced colony formation and anchorage-independent growth inhibited by elevated expression of Purα in NIH3T3 cells

✍ Sharon M. Barr; Edward M. Johnson 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

## Abstract Levels of Purα, a conserved, sequence‐specific single‐stranded DNA and RNA binding protein, fluctuate during the cell cycle, declining at the onset of S‐phase and peaking at mitosis. In early G1 Purα is associated with the hypophosphorylated form of the retinoblastoma protein, Rb. Micro