PET imaging of norepinephrine transporter in cocaine abuser using (S,S)-[11C]MRB
โ Scribed by T. Singhal; B. Planeta-Wilson; J.D. Gallezot; S. Henry; N. Nabulsi; D. Labaree; J. Ropchan; R.E. Carson; A. Neumeister; R.T. Malison; Y.-S. Ding
- Book ID
- 118491168
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 62 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1053-8119
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The concentration (Bmax) of the dopamine transporter (DAT) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n ฯญ 12) by using [ 11 C]cocaine as a radiotracer for the DAT and positron emission tomography (PET). Two
## Abstract __Introduction:__ (__R__)โ3โ(2โ(methylthio)phenoxy)โ__N__โmethylโ3โphenylpropanโ1โamine [(__R__)โthionisoxetine; **1**] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label **1** with carbonโ11 (__t__~1/2~ = 20.4 min) for evaluation as a radioligand for imagi