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PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

✍ Scribed by de Paula Faria, Daniele; Copray, Sjef; Sijbesma, Jurgen W. A.; Willemsen, Antoon T. M.; Buchpiguel, Carlos A.; Dierckx, Rudi A. J. O.; de Vries, Erik F. J.


Book ID
121557937
Publisher
Springer
Year
2014
Tongue
English
Weight
530 KB
Volume
41
Category
Article
ISSN
0340-6997

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The phosphodiesterase type IV (PDEIV) family of enzymes contributes to the metabolism of cAMP formed by the stimulation of beta-adrenergic, A2-adenosine, and H2-histamine receptors in the brain. Disturbances in cAMP-mediated signaling have been implicated in several neuropsychiatric disorders, and t