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PET imaging of dopamine transporters in the human brain using [11C]-β-CPPIT, a cocaine derivative lacking the 2β-ester function

✍ Scribed by Roland D Schönbächler; Pascale M Gucker; Michele Arigoni; Stefan Kneifel; Franz X Vollenweider; Alfred Buck; Cyrill Burger; Thomas Berthold; Matthias Brühlmeier; P.August Schubiger; Simon M Ametamey

Book ID
117687776
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
211 KB
Volume
29
Category
Article
ISSN
0969-8051

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The cocaine analogue P-CIT-FE (N-(2-fluoroethyl)-2~-carbomethoxy-3~-(4-iodopheny1)nortropane) was labeled with ' lC for positron emission tomography (PET) studies of the dopamine transporter. After intravenous administration to a cynomolgus monkey, ["CIP-CIT-FE accumulated in the striatum with a str