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PET Evidence of GABAergic Dysfunction in Essential Tremor

✍ Scribed by H Boecker; A Weindl; C Liedtke; M Miederer; T Sprenger; K Wagner; I Miederer


Book ID
119587216
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
125 KB
Volume
47
Category
Article
ISSN
1053-8119

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## Abstract We measured expression of central nervous system GABA‐A receptors with ^11^C‐flumazenil (^11^C‐FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced ^11^C‐FMZ binding potential (BP) in motor‐premotor cortex, and increased ^11^C‐FMZ BP in the cerebellar nuclei.