Pestalotheols E–H: Antimicrobial Metabolites from an Endophytic Fungus Isolated from the Tree Arbutus unedo

✍ Scribed by Song Qin; Karsten Krohn; Hidayat Hussain; Barbara Schulz; Siegfried Draeger

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 249 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201100568

✦ Synopsis

Abstract

Four new compounds, pestalotheols E–H (1–4), along with one known metabolite, anofinic acid (5), were isolated from a fungal endophyte, an unidentified Ascomycete. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the relative stereochemistries of pestalotheols E–H (1–4) were confirmed by NOESY experiments. Compounds 1–5 showed good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca; compounds 3–5 showed strong antibacterial activity.