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Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation

✍ Scribed by Glaaser, Ian W.; Osteen, Jeremiah D.; Puckerin, Akil; Sampson, Kevin J.; Jin, Xiangshu; Kass, Robert S.


Book ID
121397720
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
821 KB
Volume
3
Category
Article
ISSN
2041-1723

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Long QT syndrome (LQTS) is a heterogeneous disorder caused by mutations of at least five different loci. Three of these, LQT1, LQT2, and LQT5, encode potassium channel subunits. LQT3 encodes the cardiac-specific sodium channel, SCN5A. Previously reported LQTS-associated mutations of SCN5A include a