Perspectives in Inflammation: Future Trends and Developments

✍ Scribed by J. Symoens (auth.), D. A. Willoughby, J. P. Giroud, G. P. Velo (eds.)

• Publisher: Springer Netherlands
• Year: 1977
• Tongue: English
• Leaves: 619
• Series: Future Trends in Inflammation 3
• Edition: 1
• Category: Library

✦ Synopsis

This report on Future Trends in Inflammation III is the record of what is now firmly established as a series of multidisciplinary meetings organized by the European Biological Research Association. The aim of these meetings is to provide a forum for free exchange of information between basic scien­ tists of many disciplines and clinicians to provide better understanding of problems of common interest. The next major meeting wi1l be held in 1980.* The European Biological Research Association promotes scientific and clinical collaboration among the member countries ofthe EEe. It encourages exchange of information between scientists and clinicians from centres all over the world. In addition to the major international meetings small work­ shops are organized on specific problems of common interest. Once again the Editors have attempted to capture the spirit of the meeting by publishing 'verbatim' the discussion. It can be seen that the discussions were exciting and formed an important part of the meeting. It is possible that inaccuracies have crept into the discussions; if so we apologize. It was decided that the proceedings of such a meeting had maximum value with rapid publication. We would like to thank the participants for the enthusiasm and goodwill which persisted throughout the meeting both scientifically and socially. Above all we wish to thank H.R.H. The Duchess of Kent for acting as Patron of this meeting.

✦ Table of Contents

Front Matter....Pages i-xxi
Front Matter....Pages 1-10
The rationale of using levamisole in the treatment of rheumatoid arthritis....Pages 11-20
Immunostimulation, levamisole and rheumatoid arthritis....Pages 21-27
The effect of cytotoxic drugs on the formation of mononuclear phagocytes....Pages 29-37
Rheumatoid factor-immunoglobulin G complex precipitation and neutrophil stimulation: an in vitro model for rheumatoid inflammation....Pages 39-48
Front Matter....Pages 61-67
A model for assessing effects of drugs on granulocyte emigration in vivo ....Pages 69-74
A polymorph abnormality in Crohn’s disease....Pages 75-79
The origin and kinetics of liver macrophages during steady state and inflammation ( Abstract )....Pages 81-83
Lymphocyte-mediated eosinophilia in guinea pigs with delayed hypersensitivity to a chemical....Pages 85-100
A role for L-lymphocytes in chronic inflammation....Pages 101-113
Cartilage degradation by macrophages, fibroblasts and synovial cells in culture. An in vitro model suitable for studies on rheumatoid arthritis....Pages 115-129
Adjuvant arthritis: immune responses and effects of Tilorone or interferon in partially suppressing the disease....Pages 131-146
Front Matter....Pages 161-167
The effect of local elevation of leukocyte cyclic AMP content on lysosomal enzyme release during acute inflammation in vivo ....Pages 169-178
Recent studies on the secretory activity of mononuclear phagocytes with special reference to prostaglandins....Pages 179-189
Interactions of macrophages and complement components in the pathogenesis of chronic inflammation....Pages 191-209
Matrix vesicles and apatite nodules in arthritic cartilage....Pages 211-223
Crystal induced inflammation and osteoarthritis....Pages 225-231
Microanalysis of particulate material involved in inflammation....Pages 233-237
The influence of chemical composition of plasma membranes on the functional activities of macrophages....Pages 239-250
Front Matter....Pages 263-263
Dual function of E-type prostaglandins in models of chronic inflammation....Pages 265-277
Interactions between prostaglandin E and cyclic nucleotides in chronic inflammatory disease....Pages 279-288
Front Matter....Pages 263-263
The time course of the vascular events associated with inflammation due to ultraviolet irradiation of guinea pig ears....Pages 289-294
Role of macrophages in D-penicillamine-induced stimulation of DNA synthesis in lymph node cells....Pages 295-302
Anti-inflammatory effects of tumour bearing....Pages 303-316
Role of platelets and of prostaglandin synthetase on hypotensive effects of arachidonic acid and of carrageenan....Pages 317-330
Evidence for a pivotal role of the endoperoxide, PGG 2 , in inflammatory processes....Pages 331-337
Thiols and prostaglandin biosynthesis....Pages 339-345
Interactions of non-steroidal anti-inflammatory drugs with substance P-like and gastrointestinal hormones-like polypeptides....Pages 347-352
Salicylic acid and proquazone: the differences in absorption and biodistribution explain their different profile of side-effects....Pages 353-360
Degradation of bovine nasal cartilage by a neutral protease from human leukocyte granules....Pages 361-370
Inhibition of experimental ocular inflammation by topical application of non-steroidal anti-inflammatory drugs (NSAID)....Pages 371-381
Potentiation of acenocoumarin-induced anticoagulation by a new anti-inflammatory agent in man (Abstract) ....Pages 383-385
In vitro methods for assessing anti-inflammatory drug activity (Abstract) ....Pages 387-389
Front Matter....Pages 391-391
Potentiation of antibody formation by proteases in vivo ....Pages 393-398
Triggers of prostaglandin release from macrophages....Pages 399-404
Biological, chemical and pharmacological induction of the properdin-mediated pathway of complement activation in vitro ....Pages 405-416
Immune reactions of lymphocytes eluted from rheumatoid inflammatory tissue....Pages 419-426
Attempts at producing immune complexes in vitro between isolated macroglobulins and purified IgGs....Pages 427-434
Behaviour of some inflammation parameters in plasma and synovial fluid in some rheumatic diseases ( Abstract )....Pages 435-436
Some applications of quantitative two-dimensional immunoelectrophoresis in the study of the systemic acute-phase reaction of the rat....Pages 437-444
Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E....Pages 445-454
Front Matter....Pages 391-391
Rheumatoid-like joint lesions in rabbits injected intravenously with foreign serum....Pages 455-459
Anti-inflammatory activity of some bacterial immunostimulants. Relation with macrophage migration....Pages 461-468
Inflammatory exudates and mitogenic activity....Pages 469-479
Secretory activity of epithelioid cells....Pages 481-490
Vascular changes during acute inflammatory responses in rat hindpaws....Pages 491-495
Front Matter....Pages 497-497
Activators and inhibitors of fibrinolysis in rheumatoid joint inflammation....Pages 499-505
Relationships between increased vascular permeability, oedema, hyperalgesia and the effect of non-steroid anti-inflammatory drugs....Pages 507-518
Two sites of action of steroids on the prostaglandin system....Pages 519-525
Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein)....Pages 527-544
Humoral control of monocytopoiesis ( Abstract )....Pages 545-547
Front Matter....Pages 557-560
Difficulties in the clinical evaluation of new anti-inflammatory drugs....Pages 561-573
Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?....Pages 575-583
About immunological anomalies in treated and non-treated rheumatoid arthritis: rosette test and immunofluorescence of B-cells....Pages 585-590
Should penicillamine be prescribed for rheumatoid arthritis?....Pages 591-597
Long-term evaluation of intermittent levamisole treatment in rheumatoid arthritis....Pages 599-609
Back Matter....Pages 619-638

✦ Subjects

Rheumatology