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Perspectives and open problems in the early phases of left–right patterning

✍ Scribed by Laura N. Vandenberg; Michael Levin


Book ID
116881422
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
779 KB
Volume
20
Category
Article
ISSN
1084-9521

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Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an