Role of asymmetric signals in left-right
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Hamada, Hiroshi ;Meno, Chikara ;Saijoh, Yukio ;Adachi, Hitoshi ;Yashiro, Kenta ;
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Article
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2001
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John Wiley and Sons
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English
⚖ 87 KB
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Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an