Personality dependent effects of the ACTH 4–10 fragment on test performances and on concomitant autonomic reactions
✍ Scribed by Christoph Breier; Herbert Kain; Heribert Konzett
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 619 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of the ACTH-fragment 4-10 (30 mg SC) on a mental performance test and on some concomitant cardiovascular changes was investigated in comparison with a placebo in a double blind cross-over study. The subjects were either mainly extraverted or mainly introverted according to Eysenck's 'Maudsley Personality Inventory'. Under the influence of the heptapeptide extraverted subjects achieved a higher total score in the mental task performance with a smaller increase of forearm blood flow and of heart rate than under the influence of the placebo.
In contrast, under the influence of the placebo introverted subjects achieved a higher total score in the mental task performance with a smaller increase of forearm blood flow and of heart rate than under the influence of the ACTH-fragment. Personality, therefore, determines to some degree how this centrally acting heptapeptide influences efficiency in the mental task performance and the concomitant cardiovascular changes.