Persistent sex differences in growth control of early rat liver lesions are programmed during promotion in the resistant hepatocyte model
✍ Scribed by D Liao; I Porsch-Hallstrom; J A Gustafsson; A Blanck
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 396 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
The persistent sex differentiation in focal proliferation
The effects of gonadal hormones on several parameand c-myc expression indicated that a hormone-reguters associated with sex-differentiated promotion in the lated change in growth control was introduced during resistant hepatocyte (RH) model were studied. Male and 2-AAF/PH treatment. (HEPATOLOGY 1996;23:835-839.) female rats were initiated with diethylnitrosamine and promoted with 2-acetylaminofluorene (2-AAF) and partial hepatecomy (PH). Before promotion, some female Abbreviations: 2-AAF, 2-acetylaminofluorene; RH, resistant hepatocyte; 2-AAF and partial hepatectomy (PH), male rats show PH, partial hepatectomy; GH, growth hormone; mRNA, messenger RNA; CYP2C12, cytochrome P450 2C12; GST-P, glutathione-S-transferase. a faster outgrowth of putatively preneoplastic foci and From the 1 Department of Medical Nutrition and 2 Center for Nutrition and a shorter latency time for tumor development than fe-Toxicology, Karolinska Institute, Huddinge, Sweden.
males. 17,18 Similarly, a more efficient promotion in