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Persistent increased threshold of electrical stimulation selective to motor nerve in multifocal motor neuropathy

✍ Scribed by Dr. Takanori Yokota; Yukinobu Saito; Nobuhiro Yuki; Hiroaki Tanaka

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
462 KB
Volume
19
Category
Article
ISSN
0148-639X

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✦ Synopsis

In multifocal motor neuropathy (MMN) the threshold of electrical stimulation showed a persistent, marked increase for the motor nerve which decreased after treatment with intravenous immunoglobulin or oral cyclophosphamide; whereas, the threshold was normal for the sensory nerve. This discrepancy of the thresholds for motor and sensory nerves indicates that the increased threshold for motor nerve is not caused by change in perineural capacitance, such as subperi-and endoneural edema or perineural thickening. Inching studies showed that the site of the elevated motor nerve threshold was closely associated with conduction slowing and block. For the cause of the increased threshold, therefore, we suppose the presence of a factor which interferes with reorganization of the nodal property in the remyelinative process or which directly blocks sodium channels where the blood-nerve barrier is impaired in MMN.

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