## Abstract Perinatal exposure to diethylstilbestrol (DES) induces reproductive tract cancers later in life in both humans and animals. Because there is no clear evidence that perinatal DES exposure induces gene mutation, we proposed that perinatal DES exposure causes epigenetic methylation changes
β¦ LIBER β¦
Persistent gene expression changes induced by diethylstilbestrol in the neonatal mouse uterus: Role of epigenetics in carcinogenesis
β Scribed by Fei Ling Lim; Richard A. Currie; Kate Antrobus; David J. Moore; Helen Tinwell; Jenny Odum; Jayne Harris; Susan Moreland; Jayne Wright; Ian Kimber; John Ashby; George Orphanides; Jonathan G. Moggs
- Book ID
- 108287331
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 72 KB
- Volume
- 226
- Category
- Article
- ISSN
- 0300-483X
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## Abstract **BACKGROUND:** In a previous study, we determined the effects of 17βΞ±βethynyl estradiol (EE) on gene expression using microarrays that represented approximately 9,000 genes, which was the state ofβtheβart. Higher content arrays with almost double the number of genes have since become a