Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging
✍ Scribed by Demetrius L. Dicks; Marcus Carlsson; Einar Heiberg; Alastair Martin; David Saloner; Hakan Arheden; Maythem Saeed
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 557 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To use velocity‐encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain.
Materials and Methods
A combined X‐ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n = 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size = 100–300 μm) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC‐MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction.
Results
Baseline longitudinal and radial strain did not differ between area‐at‐risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from −11.5 ± 3.2% to 1.8 ± 2.5% at 1 h (P < 0.05) and −3.9 ± 1.1% at 1 week (P < 0.05). Similarly, regional radial strain progressively declined from 23.6 ± 2.5% at baseline to 12.5 ± 3.7% at 1 h (P < 0.05) and 4.8 ± 5.0% at 1 week (P < 0.01). The size of microinfarction was not significantly different between DE‐MRI and histochemical staining.
Conclusion
PC‐MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week. J. Magn. Reson. Imaging 2009;30:69–76. © 2009 Wiley‐Liss, Inc.