Persistence of rous sarcoma virus genome in AKR mouse sarcoma cells resistant to chromomycin A3and actinomycin D

Actinomycin-D-resistant in vitro mouse c

Actinomycin-D-resistant in vitro mouse cell line derived from a methylcholanthrene-induced sarcoma: Decrease of malignancy and antigenic characteristics

✍ J. Belehradek Jr.; J. L. Biedler; M. Thonier; G. Barski 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 761 KB

## Abstract The tumorigenic EPO clonal cell line, derived from a methylcholanthrene‐induced murine sarcoma, was exposed to increasing concentrations of actinomycin D and gave rise to a subline, resistant to 0.02 μg of actinomycin D per ml of medium, which was designated EPO/ADj. Drug resistance was