Recent clinical observations support the hypothesis that persistent parvovirus B19 is a triggering factor of rheumatoid arthritis (RA) in certain genetically predisposed individuals. If this hypothesis is correct, a number of RA patients may exhibit parvovirus B19 DNA in their synovial membranes. We
Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy
✍ Scribed by Maria Söderlund; Robert von Essen; Jarkko Haapasaari; Urpo Kiistala; Olli Kiviluoto; Klaus Hedman
- Book ID
- 118560353
- Publisher
- The Lancet
- Year
- 1997
- Tongue
- English
- Weight
- 33 KB
- Volume
- 349
- Category
- Article
- ISSN
- 0140-6736
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## Abstract A progressive arthropathy develops commonly in haemophiliacs and its pathogenesis is not fully understood. Human parvovirus B19 has been associated with several diseases including acute and chronic arthropathy and some studies suggest its implication in chronic inflammatory diseases of
Acute rheumatologic symptoms are frequently associated with human parvovirus B19 (B19) infections. A nested PCR (nPCR) assay was used to test for the presence of parvovirus B19 DNA in synovial fluid and/or synovial membrane specimens obtained from a total of 90 patients with arthritis of unknown ori