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Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells

โœ Scribed by Kiyoshi Migita; Yumi Maeda; Seigo Abiru; Atsumasa Komori; Terufumi Yokoyama; Yasushi Takii; Minoru Nakamura; Hiroshi Yatsuhashi; Katsumi Eguchi; Hiromi Ishibashi


Book ID
116465627
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
409 KB
Volume
579
Category
Article
ISSN
0014-5793

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Matrix metalloproteinase-2 activation in
โœ Anne-Marie Prรฉaux; Ariane Mallat; Jeanne Tran Van Nhieu; Marie-Pia d'Ortho; Rosa ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 182 KB

Matrix metalloproteinase-2 (MMP-2) is involved in extracellular matrix remodeling. It is secreted as a proenzyme and activated by membrane type-MMPs (MT-MMP), such as MT1-MMP. In liver fibrosis, MMP-2 is highly expressed in myofibroblasts and may have a profibrogenic role. The mechanisms of its acti