Peroxisomes in lipid metabolism

✍ Scribed by Udo Seedorf

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 91 KB
• Volume: 72
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/(sici)1097-4644(1998)72:30/31+<158::aid-jcb20>3.0.co;2-0

✦ Synopsis

Gene targeting and the elucidation of mutations underlying inherited peroxisomal diseases have provided new insights in peroxisomal lipid metabolism in vivo. The work led to the identification of a novel peroxisomal ␤-oxidation pathway and established clearly that genes, which are required for efficient peroxisomal oxidation of fatty acids, at the same time are key regulators of PPAR␣ function in vivo. The new mouse models may provide helpful tools in the search for unknown natural PPAR␣ agonists and in screening for in vivo PPAR␣ antagonists.