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Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes

✍ Scribed by Hassan Afif, Mohamed Benderdour, Leandra Mfuna-Endam…

Book ID: 120706443
Publisher: BioMed Central
Year: 2007
Tongue: English
Weight: 784 KB
Volume: 9
Category: Article
ISSN: 1478-6354
DOI: 10.1186/ar2151

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## Objective: To determine the effects of peroxisome proliferator-activated receptor gamma (ppargamma) agonists on interleukin-1 (il-1) induction of nitric oxide (no) and matrix metalloproteinase 13 (mmp-13) in human chondrocytes. ## Methods: Ppargamma expression and synthesis in human chondrocyt