Peroxisome proliferator-activated receptor-γ activation attenuates motor and cognition impairments induced by bile duct ligation in a rat model of hepatic cirrhosis

Brain edema and inflammatory activation

Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis

✍ Rodrigo Jover; Regina Rodrigo; Vicente Felipo; Ricardo Insausti; Javier Sáez-Val 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

Studies of the pathogenesis of hepatic encephalopathy are hampered by the lack of a satisfactory animal model. We examined the neurological features of rats after bile duct ligation fed a hyperammonemic diet (BDL+HD). Six groups were studied: sham, sham pair-fed, hyperammonemic, bile duct ligation (