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Peroxisome matrix and membrane protein biogenesis

✍ Scribed by Changle Ma; Suresh Subramani

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
163 KB
Volume
61
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Peroxisomes play an important role in lipid metabolic pathways and are implicated in many human disorders. Their biogenesis has been studied over the last two decades using many uni and multi‐cellular model systems and many aspects of the mechanisms and proteins involved in peroxisome biogenesis are conserved from yeast to humans. In this manuscript we review the recent progress made in our understanding of the mechanisms by which matrix and membrane proteins are sorted to and assembled into peroxisomes. Β© 2009 IUBMB IUBMB Life 61(7): 713–722, 2009

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During the last few years much has been learned regarding signals that target proteins into peroxisomes. The emphasis in the near future will undoubtedly shift towards the elucidation of the mechanism of import. The use of mammalian and yeast cells deficient in peroxisome assembly and/or import (Zoe