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Permeation Models and Structure-Function Relationships in Ion Channels

✍ Scribed by Serdar Kuyucak; Shin-Ho Chung


Book ID
110391822
Publisher
Springer Netherlands
Year
2002
Tongue
English
Weight
149 KB
Volume
28
Category
Article
ISSN
0092-0606

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## Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups repr