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Permeability of the rat bladder to cisplatinum under different conditions: Comparison with mitomycin C and adriamycin

✍ Scribed by Engelmann, U. ;Oelsner, G. ;B�rger, R. A. ;Wagner, H.

Publisher: Springer
Year: 1983
Tongue: English
Weight: 318 KB
Volume: 11
Category: Article
ISSN: 0300-5623
DOI: 10.1007/bf00272708

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✦ Synopsis

In 50 female Sprague-Dawley rats the absorption of Cisplatinum through the bladder wall was studied. Under different conditions, including cystitis and electrocoagulation of the bladder mucosa, the absorption was low and the measureable serum concentrations did not exceed 2.64 micrograms/ml. The influence of Tween 80--a non-ionic surfactant--on the absorption is investigated. The results are compared with those found for Adriamycin and Mitomycin C under identical conditions.