Permeability of double-layer films III

✍ Scribed by Tsuneto Kuriyama; Michiharu Nobutoki; Michio Nakanishi

• Book ID: 102914555
• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 588 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600591009

✦ Synopsis

administration of the nonsustained-release tablet, with the rate decreasing after the 24-hr. point.

The mean equivalent pentylenetetrazol excretion values and the standard deviations for the three groups are given in Table 111. Student i values (8) were calculated to compare the mean excretion values of the different groups at various times. Statistically significant ( p = 0.01) differences were seen between Groups A and B at allcollection intervals after the first ((t3 hr.).

No significant differences between Groups A and C were present at any of the collection intervals. These results indicate that urinary excretion of 300 mg. of pentylenetetrazol proceeds at approximately the same rate whether the dose is administered in one sustained-release tablet or divided and administered in three doses at 4-hr. intervals. These results also indicate that the same fraction of pentylenetetrazol was absorbed from the sustained-release tablets as from the nonsustained-release tablets.

There were no significant differences between Groups B and C until the fourth collection (9-12 hr.). Mean excretion values for these two groups were significantly different in all of the last five urine collections.