Permanent cerebellar toxicity of cytosine arabinoside (Ara C) in a young woman
โ Scribed by Joseph H. Friedman; Neetha Shetty
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 840 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.1098
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
This report provides the first videotape example of a patient with permanent cerebellar ataxia from high dose cytosine arabinoside. This case was unusual in that the patient was young, the effects are seemingly permanent and severe, and corticospinal tract damage also occurred. Early recognition to stop drug administration remains the only method to reduce risk.
๐ SIMILAR VOLUMES
Thirty-four patients with refractory or recurrent high grade non-Hodgkin's lymphoma (NHL) or acute leukemia were treated with a combination of etoposide, 100 mg/mZ daily, and ara C, 1 g/m2 twice daily, for 5 days (VPARAC). This therapy was given in the anticipation that remissions thus achieved woul