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Peripheral T-cell self-reactivity and immunological memory

✍ Scribed by George A DosReis; Ethan M Shevach

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 104 KB
Volume: 19
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(98)01369-3

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✦ Synopsis

human lymphocytes. These results suggest that the common immunological epitope within gp41 induces increased levels of antibodies that can interact with IFN-␣ and IFN-␤.

Gringeri et al. demonstrated that HIVinfected patients treated with an IFN-␣ vaccine showed a significant reduction in the rate of disease progression, which was associated with an increase in IFN-␣ antibody titer and an increase in IFN-␣-neutralizing capacity. The anti-IFN-␣ antibody was shown to recognize aa560-599 of HIV-1 gp41 (Ref. 7). These data suggest that the common immunological epitope within receptor binding sites may be associated with protective activity. Interestingly, a similar epitope in SIV gp32 could protect macaques from SIV infection 8, , indicating that the common immunological epitope on gp41, IFN-␣ and IFN-␤ could be useful in the development of a vaccine strategy against HIV-infection.

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