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Peripheral neuropathy in cold agglutinin disease

✍ Scribed by MD T. Darrell Thomas; MD Peter D. Donofrio; MD Jean Angelo

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
339 KB
Volume
14
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

Cold agglutinin disease (CAD) characteristically presents as anemia and cold‐induced rash. We report a man with purpura, anemia, cold agglutinins, and a sensory‐autonomic polyneuropathy. Treatment with corticosteroids and plasma exchange resulted in resolution of the anemia and polyneuropathy. We propose that CAD may be associated with a reversible sensory‐autonomic neuropathy in the absence of cryoglobulinemia. Although unsupported by pathologic findings, pathogenetic hypotheses for the neuropathy in CAD are similar to those proposed for cryoglobulinemic neuropathy.

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