High titers of serum antibodies to neural antigens occur in several forms of neuropathy. These include neuropathies associated with monoclonal gammopathy, inflammatory polyneuropathies, and paraneoplastic neuropathies. The antibodies frequently react with glycosylated cell surface molecules, includi
Peripheral neuropathy associated with monoclonal IgM autoantibody
β Scribed by Dr Andreas J. Steck; Norman Murray; Koussay Dellagi; Jean-Claude Brouet; Maxime Seligmann
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 433 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We studied the frequency and clinical correlates of different IgM specificities in 75 patients with neuropathy associated with IgM monoclonal gammopathy. Patients were tested for IgM reactivity with the myelinβassociated glycoprotein, PO, neurofilaments, and tubulin by immunoblot; with
Forty cases of polyneuropathy associated with IgM monoclonal gammopathy were retrospectively studied to investigate the relevance of clinical and electrophysiological features to M-protein antibody activity. There were 26 men and 14 women; mean age was 65 Β± 11.7 years at the time of the study. Thirt