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Peripheral neuropathy associated with high-dose ara-C therapy

โœ Scribed by Alain Borgeat; Michelle Stalder; Benoit De Muralt

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
283 KB
Volume
58
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Central nervous system toxicity associated with high-dose cytosine arabinoside (Ara-C) therapy (HD Ara-C) is well known. The authors report the case of a severe isolated peripheral polyneuropathy due to HD Ara-C. Electrophysiologic changes and histologic observations were consistent with axonal degeneration and scattered destruction of myelin sheaths. This observation emphasizes the need for careful complete neurologic evaluation for patients receiving HD Ara-C treatment.

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