Peripheral Neuropathy After Concomitant Administration of Dimethyl Sulfoxide and Sulindac
✍ Scribed by Brian N. Swanson; Roger K. Ferguson; Neil H. Raskin; Bernard A. Wolf
- Book ID
- 101647507
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 277 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
In recent years, dimethyl sulfoxide (DMSO) has achieved widespread popularity in this country as a folk remedy for myalgia, arthritis, and athletic injuries (1). Concomitant use of DMSO with nonsteroidal antiinflammatory agents is known to occur, yet there are few studies on potential drug interactions among these various drugs. Reinstein et al (2) have recently described an arthritis patient who developed a severe peripheral neuropathy after coadministration of topical DMSO and oral sulindac. This patient had used sulindac alone consistently for 6 months without adverse effects, and then began applying DMSO liberally to his arms and legs. Aberrations in peripheral sensation were noted within a few weeks, and the patient experienced a progressive decline in muscle strength and mobility during the next 4 months. A mixed sensory-motor peripheral neuropathy of all 4 limbs was demonstrated by electromyographic and nerve conduction studies. The patient's condition improved incompletely during the year following discontinuation of both drugs. We here describe another case of peripheral neuropathy, which bears a striking resemblance to the above report.
Case report. A 68-year-old man with mild osteo-From the Jefferson Medical College, Philadelphia, and the