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Peripheral myelin protein 22: Facts and hypotheses

✍ Scribed by Dr. Ueli Suter; G. J. Snipes

Book ID
102910730
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
751 KB
Volume
40
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Mutations affecting the peripheral myelin protein 22 (PMP22) gene are associated with inherited motor and sensory neuropathies in mouse (Trembler and Trembler-J) and human (Charcot-Marie-Tooth disease type 1A and Dejerine-Sottas syndrome). Although genetic studies have established a critical role of PMP22 in the formation and/or maintenance of myelin in the peripheral nervous system, the biological function of PMP22 in myelin and in non-myelin forming cells remains largely enigmatic. In this Mini-Review, we will summarize the current knowledge about PMP22 and discuss its hypothetical function(s) in a broad context. 0 1995 Wiley-Liss, h e .

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