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Peripheral inflammation is associated with remote global gene expression changes in the brain

✍ Scribed by Thomson, Carolyn A; McColl, Alison; Cavanagh, Jonathan; Graham, Gerard J

Book ID
125401978
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
449 KB
Volume
11
Category
Article
ISSN
1742-2094

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## Abstract It is well established that mediators of peripheral inflammation are relayed to the brain and elicit sickness behavior via neuroinflammatory agents that target neuronal substrates. In the present study, we used double‐stranded RNA (dsRNA), a viral replication intermediate, to mimic the