## Abstract We pursued a breeding strategy intended to generate disease‐resistant mice with exclusive expression of the H‐2^u^‐restricted myelin basic protein (MBP) 1‐11 peptide‐specific transgenic (Tg) T‐cell receptor (TCR) on the T‐cell‐deficient RAG1KO (H‐2^b^) background. Utilizing specific scr
✦ LIBER ✦
Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice
✍ Scribed by Shohei Hori; Matthias Haury; Juan J. Lafaille; Jocelyne Demengeot; António Coutinho
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 209 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
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Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer