Peripheral axon caliber and conduction velocity are decreased after burn injury in mice

IGF-I deficient mice show reduced periph

IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment

✍ Gao, Wei-Qiang ;Shinsky, Natasha ;Ingle, Gladys ;Beck, Klaus ;Elias, Kathleen A. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB

Although insulin-like growth factor-I (IGF-I) can act as a neurotrophic factor for peripheral neurons in vitro and in vivo following injury, the role IGF-I plays during normal development and functioning of the peripheral nervous system is unclear. Here, we report that transgenic mice with reduced l