## Abstract The metabolic and secretory properties of peripheral and synovial granulocytes of patients with rheumatoid arthritis were investigated with serumโ or immunoglobulinโtreated zymosan as activators of cell metabolism. During isolation of the synovial cells precautions were taken to prevent
Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis
โ Scribed by Corsiero, Elisa; Pitzalis, Costantino; Bombardieri, Michele
- Book ID
- 124090111
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 423 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1359-6446
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๐ SIMILAR VOLUMES
In our ongoing efforts to explain the immunopathogenesis of rheumatoid arthritis (RA), we will integrate and highlight two recent advances. The first advance is the identification of IgG autoantibodies to citrullinated peptides in a substantial (30-50%) portion of patients with RA and their role as
## Abstract ## Objective To address the ongoing debate concerning the specificity of synovial citrullinated proteins for rheumatoid arthritis (RA) and to analyze their pathophysiologic relevance to the induction or perpetuation of the RAโspecific antiโcitrullinated protein antibodies (ACPAs). ##