The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (designated trade name: Spedifen), 400 mg (-)R-ibuprofen
Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration
✍ Scribed by MATTI KYLLÖNEN; KLAUS T. OLKKOLA; TIMO SEPPÄLÄ; PAULI RYHÄNEN
- Book ID
- 109029548
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 145 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1155-5645
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The pharmacokinetic parameters of ibuprofen enantiomers after a single 600 mg dose and repeated 3 x 400 mg doses of Nurofen@ were determined in 12 healthy volunteers. Terminal half-lives were similar for both enantiomers, but plasma levels of S-ibuprofen were higher than those of R-ibuprofen, due to
The lysine salt of d,l-2-(4-isobutylphenyI)-propionic acid (ibuprofen lysine) was administered as a single oral dose of 500 mg by means of commercially available coated tablets (Imbun@).\* To assess the absolute bioavailability of ibuprofen after its oral application as a lysine salt, intravenous in