Perioperative ischaemia in aortic surgery: combined epidural/ general anaesthesia and epidural analgesia vs general anaesthesia andivanalgesia

Pharmacokinetics of epidurally administe

Pharmacokinetics of epidurally administered nicomorphine with its metabolites and glucuronide conjugates in patients undergoing pulmonary surgery during combined epidural local anaesthetic block and general anaesthesia

✍ Petronella M. Koopman-Kimenai; Tom B. Vree; Leo H. D. J. Booij; Marcel A. W. M. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 701 KB

After epidural administration of 15 mg 3,6-dinicotinoylmorphine (nicomorphine) in 10 patients undergoing pulmonary surgery, the parent compound was quickly metabolized into the metabolites 6-mononicotinoylmorphine and morphine. The mean apparent half-lives ( f SD) of elimination were 10min (0.165 h