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Pericentric chromosome 8 inversion associated with the 5′RUNX1/3′CBFA2T1gene in acute myeloid leukemia cases

✍ Scribed by L. Anelli; F. Albano; A. Zagaria; A. Liso; A. Cuneo; M. Mancini; V. Liso; M. Rocchi; G. Specchia

Publisher
Springer
Year
2004
Tongue
English
Weight
309 KB
Volume
84
Category
Article
ISSN
0939-5555

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Insertions generating the 5′RUNX1/3′CBFA
Insertions generating the 5′RUNX1/3′CBFA2T1 gene in acute myeloid leukemia cases show variable breakpoints
✍ Giorgina Specchia; Francesco Albano; Luisa Anelli; Antonella Zagaria; Arcangelo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB

Translocation t(8;21)(q22;q22) is a common karyotypic abnormality detected in about 15% of acute myeloid leukemia (AML) cases. The rearrangement results in fusion of the RUNX1 (also known as AML1) and CBFA2T1 (also known as ETO) genes, generating a 5'RUNX1/3'CBFA2T1 transcriptionally active fusion g