Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes

Periadventitial lacZ gene transfer to pi

Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid–liposome complexes

✍ Timo M. Pakkanen; Marja Laitinen; Mikko Hippeläinen; Mikko O. Hiltunen; Esko Alh 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 794 KB

## Background: Periadventitial gene therapy is a promising alternative for the treatment of stenosis, vessel wall thickening and other complications in vascular surgery. ## Methods: We compared lacz gene transfer efficiency of dotma: dope (1:1 w/w) plasmid/liposome complexes and adenoviruses in p